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DNA binding entails a nearly a hundred and eighty° rotation on the OB area all-around a swivel (denoted through the black arrow
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The peptide covalently linking the DBD and NTase area of HuLig1 is positioned in the same 6 o'clock posture over the DNA circumference as being the noncovalent kissing contacts that close the clamp in ChVLig. HuLig1 closes its clamp by contacts among the N-terminal DBD along with the C-terminal OB module, Situated at “a single o'clock” around the DNA circumference (